MediShield™ Controlled-Permeability Membrane Coatings

Implanted or wearable biosensors often need permeability control coatings to control the rate of permeation of different molecules. Medical Surface has developed the MediShield™ Controlled-Permeability Membrane Coatings for biosensors to help regulating analyte diffusion / permeation.

One example is glucose sensors used in Continuous Glucose Monitoring (CGM) technologies, which are in constant contact with body fluids, allowing glucose level to be monitored constantly. In order to ensure accurate measurements, these glucose sensors often require a glucose limiting membrane (GLM) coating that can regulate the influx of glucose to the sensing layer and reduce the influx of interfering agents. Medical Surface has developed the MediShield™ GLM Coatings for glucose sensors to meet these requirements.

This figure shows the performance of the MediShield™ GLM coatings. Uncoated glucose sensor has limited linearity range due to the high glucose to oxygen ratio in the physiological environment. Our GLM coatings are able to restrict glucose and allow maximum oxygen diffusion toward the sensor. The level of glucose restriction can be controlled precisely in our coating process. As the GLM coating becomes more restrictive for glucose permeation (In the figure, GLM B is more restrictive than GLM A, and GLM C is more restrictive than GLM B), the linearity of the glucose detection becomes better.

In addition to the GLM coatings, Medical Surface also has biocompatible coatings for biosensors. The biocompatible coating layer does not restrict the permeability of glucose and other molecules, and is able to minimize protein binding and biofouling.