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The outer surfaces of implanted medical devices (including biosensors, implants, artificial joints, heart valves) come in direct sustained contact with host tissues. The host response to implanted biomaterials can significantly interfere and impair the functions of implanted materials and sensors.    Medical Surface has developed the MediShieldTM  Biocompatible Coatings (an innovative covalent hydrogel coating) to effectively limit the Foreign Body Response and to significantly extend the life of implanted materials and sensors.
MediShieldTM Biocompatible Coatings for Implanted Medical Devices and Biosensors
Platic substrates were coated with MediShield or with a traditional hydrogel coating method. For the traditional coating, both the density of the linker and the length of the hydrogel polymer were optimized for low protein binding. The results shown on the left (in red) are for the lowest protein binding results obtained by the traditional method vs the protein binding results for the MediShield coating method (in green).
Resistance to cellular adhesion The adsorption of host proteins onto the implant surface, including complement related proteins leads to an initial inflammatory response at the implant site. Monocytes and macrophages recruit other cells, resulting in the adhesion of cells to the implanted device. The MediShieldTM Biocompatible Coating has been shown to resist adhesion of cells during prolonged period of contacting blood samples.
Permeability to glucose Biosensor coatings not only need to create an effective barrier against host cells and proteins, but also need to be permeable to host analytes that are being measured. The MediShieldTM  Biocompatible Coating has been shown to be highly permeable to glucose which is essential to glucose biosensor functionality.
Uncoated and MediShield coated dialysis membranes (3.5kD MWCO) were compared side-by-side for permeability to glucose. The amount of glucose permeated through membrane was quantitated using a glucose assay kit. MediShield coating was found to have no significant effect on the permeation of glucose across the dialysis membrane.
Exceptionally low protein binding The binding of host proteins to the surface of implanted medical devices is recognized to be the beginning of the biofouling process. The MediShieldTM Biocompatible Coating has been specifically designed to resist protein adsorption and has significantly lower protein binding compared to traditional coated hydrogels.
Non-cytotoxicity The MediShieldTM Biocompatible Coating has been tested for cytotoxicity according to ISO guideline # 10993: Biological Evaluation of Medical Devices - Part 5 by Elution method and is non-cytotoxic.
Product Sub-category: Biocompatible Coatings for Implanted Medical Devices and Biosensors