© Medical Surface Inc. 2020
The outer surfaces of implanted medical devices
(including biosensors, implants, artificial joints,
heart valves) come in direct sustained contact with
host tissues. The host response to implanted
biomaterials can significantly interfere and impair
the functions of implanted materials and sensors.
Medical Surface has developed the MediShieldTM
Biocompatible Coatings (an innovative covalent
hydrogel coating) to effectively limit the Foreign
Body Response and to significantly extend the life of
implanted materials and sensors.
MediShieldTM Biocompatible Coatings
for Implanted Medical Devices and
Platic substrates were coated with
MediShield or with a traditional hydrogel
coating method. For the traditional
coating, both the density of the linker and
the length of the hydrogel polymer were
optimized for low protein binding. The
results shown on the left (in red) are for
the lowest protein binding results
obtained by the traditional method vs the
protein binding results for the MediShield
coating method (in green).
Resistance to cellular adhesion
The adsorption of host proteins onto the implant surface,
including complement related proteins leads to an initial
inflammatory response at the implant site. Monocytes
and macrophages recruit other cells, resulting in the
adhesion of cells to the implanted device. The
MediShieldTM Biocompatible Coating has been shown to
resist adhesion of cells during prolonged period of
contacting blood samples.
Permeability to glucose
Biosensor coatings not only need to create an effective barrier against host cells and proteins, but
also need to be permeable to host analytes that are being measured. The MediShieldTM
Biocompatible Coating has been shown to be highly permeable to glucose which is essential to
glucose biosensor functionality.
Uncoated and MediShield coated dialysis
membranes (3.5kD MWCO) were compared
side-by-side for permeability to glucose.
The amount of glucose permeated through
membrane was quantitated using a glucose
assay kit. MediShield coating was found to
have no significant effect on the
permeation of glucose across the dialysis
Exceptionally low protein binding
The binding of host proteins to the surface of implanted
medical devices is recognized to be the beginning of the
biofouling process. The MediShieldTM Biocompatible
Coating has been specifically designed to resist protein
adsorption and has significantly lower protein binding
compared to traditional coated hydrogels.
The MediShieldTM Biocompatible Coating has been tested for cytotoxicity according to ISO guideline #
10993: Biological Evaluation of Medical Devices - Part 5 by Elution method and is non-cytotoxic.
Product Sub-category: Biocompatible Coatings
for Implanted Medical Devices and Biosensors